连接航空公司:联合气道疾病的当前趋势
Benedetta Bondi1,2, Martina Buscema1,2, Federico Di Marco1,2
1Respiratory and Allergy Clinic, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
Journal of personalized medicine
|January 27, 2026
概括
联合呼吸道疾病 (UAD) 关联了上下呼吸道炎症,通常是由2型 (T2) 炎症驱动的. 综合诊断和向治疗,包括生物药物,对于管理这种相互关联的疾病至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
- 过敏 过敏是一种过敏.
背景情况:
- 联合呼吸道疾病 (UAD) 概念化了上呼吸道炎症状况 (例如,过敏性鼻炎,慢性鼻炎) 和下呼吸道疾病 (如喘) 的相互联系.
- 流行病学,胚胎学和免疫学数据支持将呼吸道炎症视为一个统一的过程,而不是孤立的病理.
- 2型 (T2) 炎症,其特征是细胞因子 (IL-4,IL-5,IL-13) 和细胞 (乙素,ILC2),是许多UAD表型的核心,通常是由表皮屏障功能障碍引起的.
研究的目的:
- 突出联合呼吸道疾病 (UAD) 的概念及其潜在机制.
- 强调需要一个UAD的综合诊断和管理框架.
- 讨论目前和新兴的UAD治疗策略,特别是T2高的表型.
主要方法:
- 审查支持UAD范式的流行病学,胚胎学和免疫学证据.
- 诊断工具的描述,包括临床评估,成像 (CT),过敏测试,生物标志物 (FeNO,血中乙酸蛋白,IgE) 分析和肺功能测试.
- 对治疗方法的分析,从标准的皮质类固醇和灌到先进的生物疗法 (抗IL-5/IL-5R,抗IL-4R,抗TSLP) 和手术选择 (ESS).
主要成果:
- 气道炎症被呈现为一个单一的,相互关联的过程,挑战了孤立的隔间病理的概念.
- 由特定的细胞因子驱动的T2炎症,由乙氨基和ILC2s介导,被确定为UAD的关键驱动因素.
- 与临床评估相结合的表内型评估对于最佳的UAD诊断和管理至关重要.
结论:
- 最佳的UAD管理需要采用多学科,综合的方法,将呼吸道视为一个统一的系统.
- 生物疗法为严重的T2高UAD提供了显著的好处,减少了对全身皮质类固醇和手术的依赖.
- 这是一个很棒的节目,这是一个很棒的节目.
相关概念视频
Current Trends in Nursing I
5.4K
Current trends in nursing include:
5.4K
Current Trends in Nursing II
3.5K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
3.5K
Suctioning the Oropharyngeal Airway
884
In preparing for oropharyngeal airway suctioning, a nurse must gather all necessary equipment, including a suction unit with tubing, a prepackaged suction kit, sterile gloves, water or saline for irrigation, a water-soluble lubricant, and additional personal protective equipment (such as a gown, mask, and goggles) to control infections.
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
884
Suctioning the Nasopharyngeal Airway
3.2K
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Equipment Required
3.2K
Cardiopulmonary Resuscitation II: ACLS Airway Management
624
Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
624
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
524
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
524


