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比较的元分析:唾液,血和血清miRNA资料用于检测口腔状细胞癌
Arbi Wijaya1,2, Vera Julia2, Nurtami Soedarsono3
1Division of Oral Oncology and Surgical Sciences, Graduate School of Dentistry, Tohoku University, Sendai 908-0872, Miyagi, Japan.
血清衍生的microRNAs (miRNAs) 在口腔状细胞癌 (OSCC) 检测中显示出最高的准确性. 然而,生物流体类型,包括唾液,血清和血,在本次元分析中没有显著影响诊断性能.
科学领域:
- 生物标志物 生物标志物
- 分子诊断学 分子诊断
- 在瘤学瘤学.
背景情况:
- 微RNAs (miRNAs) 是对早期口腔状细胞癌 (OSCC) 检测有希望的微侵入性生物标志物.
- 在唾液,血清和血中循环的miRNAs的比较诊断性能仍然不清楚.
研究的目的:
- 系统地评估和比较唾液,血清和血衍生的miRNA用于OSCC检测的诊断性能.
- 确定生物流体类型是否影响基于miRNA的OSCC诊断的准确性.
主要方法:
- 对19项符合条件的研究进行了全面的元分析.
- 选了PubMed,MEDLINE,Scopus和CINAHL数据库. 这些数据库被选.
- 随机效应的两变模型和元回归被用来评估聚合的诊断准确性和生物流体效应.
主要成果:
- 血清衍生的miRNAs显示了最高的聚合灵敏度 (0.82),特异性 (0.88),和AUC (0.91).
- 唾液 (AUC:0.84) 和血 (AUC:0.85) 显示了可比的诊断性能.
- 超回归表明,生物流体类型对诊断性能没有统计学上显著的影响 (p = 0.903).
结论:
- 血清衍生的miRNAs在评估的生物流体中表现出OSCC检测的最佳整体诊断准确性.
- 尽管存在数值差异,但生物流体类型并不是基于miRNA的OSCC检测诊断性能的重要决定因素.
- 这些发现支持循环miRNAs作为OSCC可靠生物标志物的潜力,无论生物流体来源如何.
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