膜黑色素瘤中的循环瘤细胞:多标志物检测和与疾病状态的关联
Daniel P de Bruyn1,2, Fabiana Lucia Bassil1,2, Mike Wu1,2
1Department of Ophthalmology, Erasmus MC, The Netherlands.
Investigative ophthalmology & visual science
|January 27, 2026
概括
循环瘤细胞 (CTC) 可以检测到在大多数皮膜黑色素瘤 (UM) 患者. 较高的CTC计数表明转移性疾病,并在放射治疗期间增加,这表明分子分析的潜力.
科学领域:
- 眼科医生 眼科 眼科
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 卵巢黑色素瘤 (UM) 治疗往往限制了分子分析的组织.
- 循环瘤细胞 (CTC) 为基因组瘤分析提供了一种微创方法.
研究的目的:
- 在UM患者中评估多标志物CTC捕获的可行性.
- 在诊断时评估CTC,在分成型立体辐射疗法 (fSRT) 期间以及转移性进展时.
主要方法:
- 预期招募UM患者 (局部化和转移性).
- 在基线,fSRT期间和转移检测时采集周围血液.
- 通过光显微镜捕获和计数多标记CTC.
主要成果:
- 在局部和83.3%的转移性UM患者中检测到69.1%的CTC.
- 在转移性疾病和局部疾病中,CTC计数显著增加 (中位数为8比3).
- 在fSRT (第3天与第5天) 期间观察到增加的CTC计数.
结论:
- 多标志物CTC检测在UM患者中可行,跨疾病阶段.
- 在fSRT期间升高的CTC可能使分子表征成为可能.
- 需要进一步的研究来证实临床和预后效用.
相关概念视频
Association Areas of the Cortex
9.2K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.2K
Fetal Circulation
2.8K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.8K
Associative Learning
1.3K
Associative learning is a fundamental concept in behavioral psychology, wherein a connection is established between two stimuli or events, leading to a learned response. This process is critical in understanding how behaviors are acquired and modified. Conditioning, the mechanism through which associations are formed, can be divided into two main types: classical conditioning and operant conditioning, each elucidating different aspects of associative learning.
Classical conditioning, also known...
Classical conditioning, also known...
1.3K
Coronary Circulation
7.1K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.1K
Overview of Pulmonary Circulation
3.0K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.0K
Overview of Systemic and Pulmonary Circulation
10.7K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
The oxygenated blood is sent...
10.7K


