母亲维生素D状况,氧化应激以及对新生儿发育的影响:一项跨部门研究
Tania Flores-Bazán1, Jacqueline Scarlett Barreto-González2, José Pedraza-Chaverri3
1Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, México.
Metabolites
|January 27, 2026
概括
怀孕晚期的维生素D不足是常见的,与较低的抗氧化剂水平和婴儿出生体重较高有关. 这凸显了维生素D状况对母亲和新生儿健康的重要性.
科学领域:
- 生殖生物学和母亲健康
- 营养科学和代谢
- 生物化学和氧化应激作用
背景情况:
- 维生素D (VD) 在怀孕期间对平衡至关重要,并影响氧化还原过程.
- 维生素D缺乏 (VDD) 与不良妊娠结果有关,但与抗氧化剂标志物和新生儿结果的关联,特别是在第三个三个月,需要进一步澄清.
- 维生素D不足 (VDI) 的患病率及其对母亲的氧化还原状态及其对怀孕后期新生儿的结果的影响尚不完全理解.
研究的目的:
- 为了确定维生素D缺乏症 (VDI) 在孕妇第三季度的患病率.
- 检查母亲VDI,抗氧化剂相关生物标志物和新生儿结局之间的关联.
- 为了研究母体血清25-氧维生素D (25-OHD) 和氧化还原标记物之间的关系.
主要方法:
- 在墨西哥城,对第三个月的孕妇进行了横截面研究.
- 测量母亲血清中的25-氧维生素D (25-OHD) 和氧化还原标记物 (DPPH,GSH,GST,GPx,ORAC).
- 记录新生儿人类学参数和统计分析的协会.
主要成果:
- 在研究群体中观察到的维生素D缺乏症 (VDI) 的高患病率.
- 母亲VDI与减少的谷氨 (GSH),谷氨S转移酶 (GST) 和谷氨过氧化酶 (GPx) 活动相关.
- 患有VDI的母亲产生的新生儿出生时体重较高;母亲的25-OHD与抗氧化酶活性有积极的相关性.
结论:
- 第三个三个月的维生素D缺乏症 (VDI) 与环境因素,改变的母体氧化还原标记物和特定的新生儿结局同时发生.
- 在怀孕晚期的低最佳静脉疾病状态与氧化还原相关标记物的变化有关.
- 需要进一步的纵向和机制研究来阐明这些发现的时间序列和生物学意义.
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