乳酸在瘤生物学中的作用
Cristina Cruz1,2, Ignasi Barba1,2
1Faculty of Medicine, Universitat de Vic-Universitat Central de Catalunya (UVic-UCC), 08500 Vic, Spain.
Metabolites
|January 27, 2026
概括
乳酸,最初被视为代谢副产品,积极推动瘤的进展. 这篇综述强调了其在抑制免疫力,促进转移和影响瘤微环境 (TME) 内基因表达方面的关键作用.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 瘤微环境 (TME) 研究研究
背景情况:
- 乳酸在TME中度很高,通常超过40mM.
- 最初被认为是华堡效应 (有氧糖解) 的副产品,其作用现在被认为更复杂.
- 高乳酸水平与患者的不良结果有关,包括转移的增加和生存率的降低.
研究的目的:
- 审查高乳酸在TME中的多方面的作用.
- 探索乳酸对瘤进展和生物学的影响.
- 总结当前关于乳酸影响的知识,不仅仅是简单的代谢副产品.
主要方法:
- 对TME中乳酸的当前研究的文献综述.
- 对研究的分析,这些研究将乳酸水平与瘤进展标志物相关联.
- 检查乳酸在免疫抑制,转移和表观遗传调节中的作用的证据.
主要成果:
- 在TME中乳酸的升高抑制了抗瘤免疫反应.
- 乳酸积极促进瘤转移和细胞衰老.
- 新出现的证据表明,乳酸可以通过表观遗传机制调节基因表达,比如基因素乳化.
结论:
- 乳酸是瘤生物学中的关键参与者,而不仅仅是代谢的副产品.
- 了解乳酸在TME中的作用对于开发新的癌症疗法至关重要.
- 对表观遗传修饰的进一步研究,如乳糖化,可能会揭示新的治疗点.
相关概念视频
What is Conservation Biology?
24.3K
Conservation biology is a scientific field that focuses on the preservation of biodiversity in order to protect ecosystems while meeting the needs of the human population. Humans require properly functioning ecosystems to maintain our supply of natural resources, including food, medicines, and building materials.
24.3K
Biological Effects of Radiation
17.8K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
17.8K
Amino acids
105.1K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
105.1K
Mixtures of Acids
21.7K
The pH of a solution containing an acid can be determined using its acid dissociation constant and its initial concentration. If a solution contains two different acids, then its pH can be determined using one of several methods depending upon the relative strength of the acids and their dissociation constants.
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
A Mixture of a Strong Acid and a Weak Acid
In a mixture of a strong acid and a weak acid, the strong acid dissociates completely and becomes a source of almost all the hydronium ions...
21.7K
Polyprotic Acids
31.9K
Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
31.9K
Nucleic acids
189.3K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
189.3K


