通过酶性水解从渔业副捕获中提取的抗菌的蛋白质和功能性特征
Vicky Balesteros S Blumen Galendi1, Guilherme Rabelo Coelho2, Letícia Murback1
1Botucatu Medical School (FMB), São Paulo State University (UNESP), Botucatu 18618-687, SP, Brazil.
Marine drugs
|January 27, 2026
概括
渔业的副捕获可以成为有价值的生物活性的来源. 这项研究发现,用Protamex解的Paralonchurus brasiliensis肌肉产生了强大的抗Candida,提供了一个可持续的价值化策略.
科学领域:
- 海洋生物技术 海洋生物技术
- 生物化学 生物化学
- 渔业 科学 渔业 科学
背景情况:
- 渔业的副捕获是一个生态问题,也是海洋生物质的潜在来源.
- 未充分探索的海洋生物质为生物技术应用提供了机会.
- 来自海洋生物的生物活性具有潜在的制药和营养保健用途.
研究的目的:
- 从常见的巴西海岸附捕物种中生成和表征生物活性.
- 评估海洋副捕获的生物技术潜力,以生产有价值的化合物.
- 为了确定具有显著生物活性的特定副捕获水解物.
主要方法:
- 来自Paralonchurus brasiliensis,Micropogonias furnieri和Hepatus pudibundus的肌肉组织使用Alcalase和Protamex进行了水解.
- 用SDS-PAGE,HPLC-UV,MALDI-TOF和LC-MS/MS进行形分析.
- 生物信息分析预测了生物活性,这些生物活性通过体外测试得到了验证.
主要成果:
- 酶选择显著影响了形状和生物活性.
- P.P.的Protamex水解.P.P.的P.P.的P.P.的P.P.的P.P.的P.P.的P.P.的P.P.的P.P.的P.P.的P.P.的P.P.P.的P.P.P.的P.P.P.P.P.P.P.P.P.P.P.P.P.P.P.P.P.P.P.P. 巴西白虫 (PBP) 显示了81%的Candida albicans的抑制.
- 酸酸解的P.P. 巴西菌 (PBA) 显示中度抑制金黄色葡萄球菌 (29%).
结论:
- 渔业的副捕获可以可持续地被利用成生物活性海洋.
- 用Protamex化的Paralonchurus brasiliensis是一种有前途的抗候群的来源.
- 这些发现支持在制药和营养品行业的应用.
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