使用L-PRF与或没有合成HA/β-TCP的前腔中短期骨愈合:一项随机临床试验
Pricila da Silva Gusmão1, Cássia Pereira da Silva1, Víctor Ravelo2,3
1Faculty of Odontology, Federal University of Juiz de Fora, Juiz de Fora 36036-900, MG, Brazil.
Journal of functional biomaterials
|January 27, 2026
概括
单独或与HA/β-TCP一起的白细胞和血小板丰富纤维素 (L-PRF) 有效地保护了牙植入物的膜脊. 虽然所有治疗都促进了骨的形成,但在8周后,天然血块在新骨形成方面表现出了卓越的结果.
科学领域:
- 口腔外科手术和再生医学
- 生物材料和组织工程
背景情况:
- 拔牙可能会对膜骨和软组织产生负面影响,使牙植入物放置复杂化.
- 富含白细胞和血小板纤维素 (L-PRF) 是一种用于增强伤口愈合和组织再生的生物材料.
- 接种材料通常用于膜脊的保存,以确保成功的植入结果.
研究的目的:
- 评估和比较单独使用L-PRF与与双相酸移植 (HA/β-TCP) 结合使用L-PRF的疗效,用于提取后的口愈合.
- 为了评估新的骨形成 (NBF) 和八周后适合随后的牙植入物放置.
主要方法:
- 十五名需要保持膜脊的患者接受了牙拔除和立即插座移植.
- 插槽被随机分为四组:对照组 (血栓),自身骨移植 (AB),L-PRF膜 (LPRF) 和具有HA/β-TCP (LPRFHA) 的L-PRF.
- 在8周的骨活检中,用ImageJ软件量化了NBF;采用单向ANOVA进行统计分析.
主要成果:
- 自生骨移植,L-PRF和L-PRFHA组之间没有发现NBF的显著差异.
- 在L-PRF和自生骨移植中,可比性新骨形成的结果是相似的.
- 对照组 (仅血液凝块) 的NBF (62.4%) 与LPRFHA组 (55.8%) 相比显著增加.
结论:
- 单独使用或与HA/β-TCP结合使用的L-PRF是一种可行的选择,可以在大腔口中保存膜脊.
- 这些治疗方法有助于有效地保护牙脊,使牙植入物在八周的早期装载成为可能.
- 尽管所有组的骨形成都取得了成功,但天然血块产生了最高的新骨百分比.
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