三层复合纳米纤维伤口包裹 结合Glucantime和银纳米颗粒用于皮肤Leishmaniasis管理
Hilal Topuz1,2, Murat Inal3, Atiye Turker1,4
1Department of Bioengineering, Faculty of Chemical and Metallurgical, Yildiz Technical University, Istanbul 34210, Turkey.
Journal of functional biomaterials
|January 27, 2026
概括
一种新的三层伤口包裹用银纳米粒子和Glucantime显示对皮肤Leishmaniasis的强有力的活性. 这种创新的治疗方法提高了药物输送,并降低了毒性,以有效地管理皮肤病变.
科学领域:
- 生物材料科学 生物材料科学
- 寄生虫学的寄生虫学
- 纳米技术 纳米技术
背景情况:
- 皮肤莱什曼病导致慢性皮肤病变,目前的治疗方法面临诸如全身副作用和病变透性差等挑战.
- 创新的本地药物输送系统对于提高莱什曼病治疗的疗效和降低毒性至关重要.
研究的目的:
- 开发和评估一种新型的三层伤口包裹,其中包含银纳米粒子 (AgNPs) 和Glucantime用于皮肤Leishmaniasis治疗.
- 为了评估制造的电纳米纤维的抗寄生虫活性,生物相容性和药物释放特性.
主要方法:
- 使用 прополис提取物进行AgNP的绿色合成.
- 通过电制造三层伤口包裹,结合聚乙烯醇,凝,AgNPs和Glucantime.
- 使用SEM-EDX,FTIR,TGA进行表征;评估水友性,抗氧化活性和双相释放.
- 在体外对 Leishmania tropica 的生物评估,评估前羊的生存能力和前羊感染指数.
主要成果:
- 鉴定证实了纳米纤维的统一形态,所需的化学结构和热稳定性.
- 三层敷料表现出水友性,抗氧化特性和双相药物释放.
- 观察到AgNP和含Glucantime的纳米纤维显著降低了Leishmania tropica前虫活力和前虫感染指数.
- 这种三层配方表现出协同效果,单独优于装载AgNP的纤维.
结论:
- 开发的三层纳米纤维伤口包裹通过增强药物输送和表现出协同抗寄生虫活性,有效治疗皮肤莱什曼病.
- 装有AgNP和Glucantime的纳米纤维是生物相容的,为局部莱什曼病治疗提供了一个有希望和安全的平台.
相关概念视频
03:35Classifying Matter by Composition
90.1K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.1K
01:21Layers of the Epidermis
8.0K
The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
8.0K
01:22Composition of Blood
12.0K
The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...
Formed elements constitute the remaining 45% of the blood volume. These...
12.0K
00:55Composite Bodies
1.4K
A composite body is a body made up of multiple parts, connected to form a larger, unified object. Each part has its own weight and center of gravity, which must be considered to determine the center of gravity of the composite body. In cases where the density or specific weight is constant, the center of gravity coincides with the centroid.
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
Composite bodies have widespread applications in mechanical engineering, from automobiles to aircraft to rockets. For example, an automobile wheel comprises...
1.4K
01:30Thematic Layering in GIS
344
In the past, planning projects such as schools or public facilities required extensive manual effort to gather and compile data. Information such as property boundaries, soil characteristics, road networks, zoning regulations, and flood zones had to be sourced individually from courthouses, utility providers, and registry offices. Assembling these datasets into a coherent format often took several months, delaying project timelines.The introduction of Geographic Information Systems (GIS)...
344
01:29Composition of Body Fluids
2.5K
Water functions as a solvent accommodating various solutes, which can be categorized under electrolytes and non-electrolytes. Non-electrolytes are usually held together by covalent bonds, restricting them from dissociating in solution, thereby leading to a lack of electrically charged components upon dissolving in water. They are predominantly organic molecules, such as glucose, creatinine, and urea. Electrolytes, on the other hand, are compounds that can break down into ions in water.
2.5K