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Updated: Jan 28, 2026

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索里亚姆费托尔用于早晨轮班工作障碍过度嗜睡
Kirsi-Marja Zitting1,2, Katherine R Gilmore1, Brandon J Lockyer1
1Brigham and Women's Hospital, Boston, MA, USA.
NEJM evidence
|January 27, 2026
概括
索里亚美醇有效地治疗了轮班工作障碍 (SWD) 的清晨轮班工人过度嗜睡. 这项研究发现,与安慰剂相比,客观和主观睡眠明显改善.
科学领域:
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 轮班工作障碍 (SWD) 影响了许多清晨轮班工作者.
- 对这种人群中SWD的有效治疗方法的研究是有限的.
研究的目的:
- 评估solriamfetol在治疗早晨轮班工人患有SWD的过度嗜睡的疗效.
- 评估solriamfetol对客观和主观嗜睡的影响.
主要方法:
- 这是一项随机,双盲,安慰剂对照试验,涉及78名患有SWD的早晨轮班工人.
- 主要结局:通过保持清醒测试改变睡眠延迟.
- 二次结果:主观的嗜睡 (卡罗林斯卡嗜睡量表) 和临床的全球印象量表.
主要成果:
- 与安慰剂相比,Solriamfetol显著降低了睡眠 (睡眠延迟时间长9.4分钟;P<0.001).
- 在主观嗜睡和临床医生/患者总体评级中观察到改善.
- 最常见的不良事件是头痛和恶心,在各组之间总体发生率相似.
结论:
- 索里亚美醇在改善早晨轮班工人SWD的嗜睡方面表现出显著的有效性.
- 这些发现支持solriamfetol作为这种患者群的潜在治疗选择.
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