菌毒素及其他:通过HRMS疑似查揭示物料中的多种有机污染物
Dafni Dematati1, Dimitrios Gkountouras1, Vasiliki Boti1,2
1Department of Chemistry, University of Ioannina, GR-45110 Ioannina, Greece.
Toxins
|January 27, 2026
概括
大多数物料含有有机污染物,如真菌毒素和农药. 这项研究确定了29种化合物,超过75%的样本含有真菌毒素,特别是在干狗和猫中.
科学领域:
- 食品科学 食品科学 食品科学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 物食品安全对于动物健康至关重要.
- 商业物料可能含有各种有机污染物.
- 关于物料中多种污染物的同时存在的数据有限.
研究的目的:
- 评估商用物料中的有机污染物.
- 识别和量化菌毒素,农药,药品和生物活性化合物.
- 评估物料中同时存在的污染物的流行率和模式.
主要方法:
- 使用QuEChERS提取方法分析了65个物料样本 (33只猫,32只狗).
- 液体染色学与线性陷四极点/轨道轨道高分辨率质谱学 (LC-LTQ/轨道轨道 HRMS) 相结合.
- 没有标准的多类污染物检测的嫌疑人选策略.
主要成果:
- 在186个检测中,初步识别了29种化合物.
- 在76.9%的样本中检测到毒素;偏毒素和T2/HT2毒素占主导地位.
- 在72%的干性料中发现杀虫剂,而在湿性料中发现11%;在23.8%的干性料中发现药物.
- 在51%的样本中发现了植物性生物活性化合物,在猫料中具有更高的相关性.
结论:
- 基于HRMS的可疑查有效地识别了物料中的多类污染物.
- 菌毒素和农药普遍存在,特别是在干物料中.
- 需要进一步的有针对性的分析来确认毒理学上相关的化合物,特别是在猫粮中.
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