在MRI中,身体脂肪分布模式与大脑结构,认知和神经疾病的关联
Miao Yu1,2, Libin Yao3, Sanjeev Shahi1
1Department of Radiology, The Affiliated Hospital of Xuzhou Medical University, No. 99 W Huaihai Rd, Xuzhou, China 221006.
Radiology
|January 27, 2026
概括
特定的身体脂肪分布模式,如胰腺占主导地位和瘦脂肪,与负面的大脑健康结果有关. 这项研究强调了脂肪存储的位置如何影响大脑结构,认知和神经疾病风险.
科学领域:
- 神经成像和放射学研究.
- 代谢和内分泌疾病 代谢和内分泌疾病
- 神经学和认知科学 神经学和认知科学
背景情况:
- 肥胖严重影响大脑结构和认知能力,但不同脂肪分布模式的具体影响尚不清楚.
- 了解不同肥胖模式如何影响神经健康对于有针对性的干预至关重要.
研究的目的:
- 通过MRI和潜伏形状分析 (LPA) 识别不同的身体脂肪分布模式.
- 研究这些已识别的脂肪分布形状与大脑结构,认知功能和神经疾病风险之间的关联.
主要方法:
- 利用来自英国生物库的前性数据,包括脑,心脏和腹部MRI扫描和健康记录.
- 在八个BMI调整的MRI衍生脂肪指标上使用隐性配置分析 (LPA) 来分类脂肪分布配置.
- 分析了大脑体积,白质完整性,认知和神经疾病风险的差异,根据性别分层.
主要成果:
- 在两性中确定了六种不同的身体脂肪分布概况,包括"胰腺占主导地位"和"瘦脂肪"模式.
- 胰腺占主导地位和瘦脂肪形状与灰质缩,白质强度增加和脑衰老加速相比,与瘦肉形状相比,显著相关.
- 这些不利的脂肪分布模式与认知能力下降和患神经系统疾病的风险增加有关.
结论:
- 潜在的个人资料分析有效地揭示了异质的身体脂肪分布模式.
- 胰腺占主导地位和瘦脂肪的分布模式与有害的神经结果特别相关,包括大脑结构变化和疾病风险增加.
- 脂肪分布,超出整体BMI,是影响大脑健康和神经疾病易感性的关键因素.
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