[在边界血清性卵巢瘤和低度血清性癌症中对卵巢外植入物进行分类的病理学间可重复性]
A S Badlaeva1,2, A V Asaturova1,2, A V Tregubova1
1National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov, Moscow, Russia.
Arkhiv patologii
|January 27, 2026
概括
病理学家面临的挑战是区分卵巢边界血清性瘤与低级血清性癌植入物. 实现一致的诊断需要标准化的算法来改善患者的预后和治疗.
科学领域:
- 妇科病理学 妇科病理学
- 瘤病理学 瘤病理学
- 瘤的基因型鉴定
背景情况:
- 精确的腹膜植入物组织型诊断对于管理卵巢边缘血清性瘤和低度血清性癌症至关重要.
- 区分卵巢外传播模式是治疗和预后的关键.
- 目前的组织学标准在主观分类和观察者间可复制性方面存在局限性.
研究的目的:
- 在病理学家中评估植入物类型分类的观察者间可重复性.
- 评估对卵巢边缘血清瘤和低度血清瘤植入物的诊断协议.
主要方法:
- 从23名患者的门/腹膜样本的33个幻灯片被妇科病理学家和瘤病理学家独立审查.
- 评估人员包括具有不同经验的专家和通用病理学家.
- 协商一致的诊断是通过妇科病理学家的多数同意来确定的.
主要成果:
- 协商一致将42.4%归类为低度血清癌转移,57.6%为边缘瘤植入物.
- 观察到总体上相当大的可重复性 (弗莱斯卡帕=0.61),但个体上的一致性有所不同 (科恩卡帕0.348-0.817).
- 妇科病理学家表现出彼此和共识的完美一致;一般病理学家有适度的一致.
结论:
- 在区分边缘性瘤植入物与低度血清癌转移方面,仍然存在重大诊断挑战.
- 观察者间的变化凸显了对标准化诊断算法的需要.
- 改善诊断准确度对于卵巢瘤患者的最佳护理至关重要.
相关概念视频
Classifying Matter by Composition
90.1K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
90.1K
Borderline Personality Disorder
595
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
Genetic and Environmental Contributions
Borderline Personality...
595
Classifying Matter by State
102.9K
Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars.
102.9K
Graded Potential
7.0K
Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
7.0K
How Data are Classified: Numerical Data
37.7K
Data that are countable or measurable in specific units are called numerical or quantitative data. Quantitative data are always numbers. Quantitative data are the result of counting or measuring the attributes of a population. Amount of money, pulse rate, weight, number of people living in a town, and number of students who opt for statistics are examples of quantitative data.
Quantitative data may be either discrete or continuous. All quantitative data that take on only specific numerical...
Quantitative data may be either discrete or continuous. All quantitative data that take on only specific numerical...
37.7K
Types of Aggregate Grading
1.4K
Aggregate grading is crucial in economically obtaining a concrete mix with adequate strength, reasonable workability, and minimal segregation. There are four types of aggregate gradation: well-graded, uniformly (or one-sized) graded, gap-graded, and open-graded.
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
1.4K


