[根据2021-2024年的尸检数据,在后COVID综合征中消化系统器官的病理学]
E A Kogan1, A D Romanovskya1, O N Kichigina1
1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Arkhiv patologii
|January 27, 2026
概括
尸体解剖显示COVID-19患者的胃肠道和肝脏损伤显著,病毒蛋白质在组织中持久. 这些发现表明,SARS-CoV-2感染可以引发新的或恶化现有的消化系统疾病.
科学领域:
- 胃肠病学 胃肠病学
- 病理学 病理学 病理学
- 病毒学 病毒学
背景情况:
- COVID-19 (冠状病毒疾病2019) 与各种器官系统并发症有关.
- 严重急性呼吸道综合征冠状病毒-2 (SARS-CoV-2) 感染对消化系统的影响需要进一步详细调查.
研究的目的:
- 进行COVID-19患者消化器官病理变化的临床和形态分析.
- 为了将尸检结果与受影响组织中SARS-CoV-2病毒蛋白质的存在相关联.
主要方法:
- 对69名COVID-19患者的尸检进行了回顾性分析,这些患者有记录的消化系统病变.
- 胃,肠,肝脏和胰腺组织的显微镜检查和免疫组织化学研究.
- 使用特定抗体检测SARS-CoV-2尖峰和核囊蛋白.
主要成果:
- 在71%的病例中观察到胃病理,包括胃炎,侵蚀和.
- 肠道病变发生在30.6%的病例中,腺癌是最常见的.
- 所有病例 (100%) 显示肝病理,如充血性肝病变和脂肪肝炎. 在82.6%的病例中,胰腺病变存在.
结论:
- COVID-19可能导致新的发作或恶化已经存在的胃,肠道,肝脏和胰腺疾病.
- 组织中持久的SARS-CoV-2核和尖端蛋白可能会导致直接和自身免疫介导的损伤.
- 这些机制可能导致COVID-19感染后的慢性消化器官疾病的发展和进展.
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