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非清细胞细胞癌具有免疫冷表型,影响对免疫检查点抑制剂的反应

Hiroki Ishihara1, Yu-Yu Liu2, Riu Yamashita3

  • 1Tokyo Women's Medical University Shinjuku-ku, Tokyo Japan.

Molecular cancer research : MCR
|January 27, 2026
PubMed
概括

与清晰细胞RCC (ccRCC) 相比,非清晰细胞癌 (nccRCC) 患者的免疫检查点抑制剂 (ICI) 治疗结果较差. 这是由于"免疫冷"瘤微环境 (TIME) 具有较少的免疫细胞,降低了ICI治疗的有效性.

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