在巨细胞中抑制METTL3可通过通过上调IRAKM调节来增强M2极化来缓解大肠炎

Yang Zhang1,2, Xin Wang1,2, Shan Cao1,2

  • 1Department of Gastroenterology, Peking University People's Hospital, Beijing, China.

概括

甲基转移酶类3 (METTL3) 调节巨细胞两极分化和肠道炎症. METTL3缺乏通过增加IRAKM促进M2巨细胞的激活,抑制炎症,并为结肠炎提供潜在的治疗点.

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