代谢综合征和与免疫相关的不良事件
Katherine Lei1, Meera J Patel2, Jialiang Liu3
1School of Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Cancer immunology, immunotherapy : CII
|January 27, 2026
概括
代谢综合征 (MetS) 在接受免疫检查点抑制剂 (ICI) 的患者中显著增加中度至严重的免疫相关不良事件 (irAE) 的风险. 需要进一步的研究来了解和管理这种增加的irAE风险.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 代谢性疾病 代谢性疾病
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,但可能会导致不可预测的免疫相关不良事件 (irAEs).
- 之前关于irAE与代谢因素的关联的研究已经产生了不一致的结果.
- 这项研究调查了ICI治疗患者中代谢综合征 (MetS) 和irAEs之间的联系.
研究的目的:
- 确定代谢综合征 (MetS) 是否与接受免疫检查点抑制剂 (ICI) 治疗的患者的免疫相关不良事件 (irAEs) 的发展有关.
- 探索通过区域贫困指数 (ADI) 测量的社区社会经济地位与irAEs之间的关系.
- 检查治疗前细胞因子水平与MetS和irAEs之间的关联.
主要方法:
- 来自178名ICI治疗患者的人口,临床,实验室和住所数据的前性收集.
- 在ICI开始时,根据5个标准 (高血压,肥胖,HbA1c升高,HDL低,甘油三升高) 评估MetS.
- 测量基线血清细胞因子/化学因子水平,并计算ADI以代表附近的社会经济地位.
主要成果:
- 56%的患者 (99/178) 在基线时有MetS.
- 患有MetS的患者患有≥2级irAE (OR2.82) 和≥3级irAE (OR3.53) 的几率明显更高.
- MetS与治疗前的细胞因子水平无关,而ADI与细胞因子相关,但与MetS或irAEs无关.
结论:
- 代谢综合征是ICI治疗患者中度和重度免疫相关不良事件的重要危险因素.
- 推动这种关联的基本机制需要进一步研究.
- 在接受ICI治疗的MetS患者中减轻irAE风险的策略需要进一步研究.
相关概念视频
What is Metabolism?
131.6K
Overview
131.6K
What is the Immune System?
127.5K
Overview
127.5K
Local Anesthetics: Adverse Effects
795
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
795
Skeletal Muscle Relaxants: Adverse Effects
805
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
805
Insulin: Dosing Regimen and Adverse Effects
744
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
744
Integration of Synaptic Events
3.7K
Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
3.7K


