头癌中与瘤相关的巨细胞:临床病理相关性和对免疫治疗的含义
Diane Evrard1,2, Aurélie Beaufrère3,4, Clément Dumont5
1Department of Otorhinolaryngology-Head and Neck Surgery, Bichat Hospital, AP-HP. Nord-Université Paris Cité, 46 Rue Henri Huchard, 75018, Paris, France. diane.evrard@aphp.fr.
Cancer immunology, immunotherapy : CII
|January 27, 2026
概括
头癌中的PD-1抑制剂可能会增加瘤相关巨细胞 (TAMs),可能阻碍治疗的有效性. 对巨细胞向策略的进一步研究对于改善免疫治疗结果至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 癌症研究 癌症研究
背景情况:
- 瘤相关巨细胞 (TAMs) 和PD-L1表达是头部和部状细胞癌 (HNSCC) 的关键.
- PD-1 抑制剂是复发性/转移性HNSCC的标准,并且越来越多地用于外科手术.
- 了解PD-1封锁对TAM动态的影响对于优化HNSCC治疗至关重要.
研究的目的:
- 调查临床特征与HNSCC中TAM患病率之间的关联.
- 探索TAMs在HNSCC进展和抵抗PD-1封锁中的作用.
- 为了分析PD-1抑制剂治疗后的TAM动态.
主要方法:
- 使用简单和多重免疫组织化学分析来自HNSCC患者的瘤样本.
- 对CD68+和CD163+巨细胞和PD-L1表达的量化.
- 使用PD-1抑制剂的新鲜瘤切片的ex vivo培养.
主要成果:
- 与喉和鼻癌相比,TAM在口腔和口腔瘤中更为丰富.
- 在PD-1免疫治疗后,TAMs密度显著增加,CD163+巨细胞聚集在瘤外围.
- 活体暴露于PD-1抑制剂重现了TAMs的增加,这表明它在免疫逃避中发挥了作用.
结论:
- 阻断PD-1可能会促进M2类巨细胞在HNSCC中的积累,这可能会导致免疫逃避.
- 这些发现凸显了在HNSCC免疫疗法中需要进一步研究和向巨细胞的策略.
- 这些见解对于HNSCC中术后免疫疗法的新兴使用尤为重要.
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