分析使用抗药物的年轻成年人眼部结构性疾病:一个横截面研究
Rajalakshmi Selvam1, Marjorie Miraclin2, Sameena Parveen Nizam2
1Department of Optometry, Dr. M.G.R Educational and Research Institute, Chennai, Tamil Nadu, 600095, India. Rajalakshmi.opt@drmgrdu.ac.in.
International ophthalmology
|January 27, 2026
概括
在年轻人中长期使用抗发作药物 (ASD) 可以导致显著的眼部并发症,包括干眼,近视和视网膜神经纤维层变薄. 定期的眼科检查对于早期发现和管理这些视觉健康问题的关键.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗发作药物 (ASD) 是主要的治疗方法,但可能导致眼部并发症.
- 关于长期治疗ASD的年轻成年人眼睛结构变化的研究有限.
- 视网膜神经纤维层 (RNFL) 稀薄和斑点是潜在的担忧.
研究的目的:
- 在使用长期自闭症的年轻人中评估折射误差,膜质量,黄斑健康和RNFL厚度.
- 为了比较ASD用户和健康对照之间的眼睛参数.
- 为了识别与眼部变化相关的特定ASD.
主要方法:
- 在340名20-40岁的成年人 (200名自闭症患者,140名对照人) 中进行了横截面研究.
- 综合眼部评估包括BCVA,折射,撕裂测试 (Schirmer,TBUT),裂纹灯检查, fundus摄影和OCT.
- 使用克鲁斯卡尔-瓦利斯H测试进行统计分析 (P < 0.05显著性).
主要成果:
- 与对照组相比,自闭症患者的折射误差显著更高,撕裂指标更低.
- 酸使用者表现出显著的膜异常.
- 在10%的ASD使用者中,OCT发现了早期的黄斑胀 (特别是与甲,托皮拉) 和平均8.5μm的RNFL稀释 (P=0.042).
结论:
- 长时间的ASD治疗与眼睛干燥,近视,黄斑胀和RNFL稀释有关.
- 这些发现强调了在患有ASD的患者中进行例行眼科评估的必要性.
- 协作护理对于预防视力障碍至关重要.
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