用[13 N]NH3 PET/CT评估的表心脂肪组织和冠状动脉功能之间的关系
Francesco Dondi1, Mattia Bertoli2, Pietro Bellini2
1Nuclear Medicine, ASST Spedali Civili di Brescia and Università degli Studi di Brescia, Brescia, 25123 , Italy. francesco.dondi@unibs.it.
The international journal of cardiovascular imaging
|January 27, 2026
概括
脊心脂肪组织 (EAT) 的体积和厚度与心肌流量储备 (MFR) 的减少有关. 增加的EAT是MFR受损的独立预测因素,这表明EAT会影响冠状动脉功能.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 生物医学成像技术 生物医学成像技术
背景情况:
- 心脂肪组织 (EAT) 越来越多地被认为与心血管疾病有关.
- 以前的研究表明,EAT会影响冠状动脉功能,心肌缺血和心脏不良事件.
- 需要进一步阐明EAT体积 (EATvol) 和厚度 (EATthick) 以及心肌血流 (MBF) 和心肌血流储备 (MFR) 之间的关系.
研究的目的:
- 调查EAT体积和厚度与心肌血流量和储量之间的关联.
- 确定EAT参数是否是MFR和MBF的独立预测因素.
- 探索EAT对冠状动脉功能的影响,使用氨PET/CT.
主要方法:
- 对164名接受[13N]氨PET/CT的患者进行了回顾性分析.
- 从未增强的CT图像中量化EAT体积 (EATvol) 和厚度 (EATthick).
- 从PET/CT图像中提取心肌血流量 (MBF) 和心肌流量储备 (MFR).
主要成果:
- 在30名受试者中观察到减少的MFR.
- 在正常和受损MFR的受试者之间,EATvol和EATthick都显著不同 (分别为p<0.001和p<0.005).
- 食量,年龄和糖尿病是MFR的独立预测因素 (分别为p=0.008,p=0.036和p=0.029). 在没有CAD病史的患者中,EATvol和糖尿病也是预测因素.
结论:
- 心脂肪组织体积与心肌流量储备受损相关.
- EAT可能在影响冠状动脉功能方面发挥重要作用.
- EATvol是MFR的独立预测指标,突出其在心血管评估中的临床相关性.
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