退院后在复杂的儿科尾炎中口服家庭抗生素的使用:系统性审查和元分析
Javier Arredondo Montero1, María Rico-Jiménez2
1Pediatric Surgery Department, Complejo Asistencial Universitario de León, C/Altos de Nava S/N, 24008, León, Castilla y León, Spain. jarredondo@saludcastillayleon.es.
World journal of pediatrics : WJP
|January 27, 2026
概括
在儿童复杂尾炎手术后,口服家庭抗生素不能减少传染性并发症或再入院. 证据质量非常低,并且不支持常规使用.
科学领域:
- 儿科手术 儿科手术
- 传染性疾病 传染性疾病
- 基于证据的医学基于证据的医学.
背景情况:
- 在儿科复杂尾炎手术中,在出院后使用口服家庭抗生素是有争议的.
- 这项研究评估了它们在预防感染并发症和再入院方面的有效性.
研究的目的:
- 系统地审查和分析口服家庭抗生素对患有复杂尾炎的儿童手术后结果的影响.
- 评估感染并发症和再入院的风险.
主要方法:
- 14项研究 (26,174名患者) 的系统综述和元分析.
- 在多个数据库中进行了搜索 (PubMed,科学网,Scopus,奥维德,Cochrane CENTRAL).
- 评估偏见风险和证据确定性 (GRADE).
主要成果:
- 在腹腔内,器官/空间感染或再入院方面没有显著差异.
- 在对照组中,手术部位感染风险较低,但这一发现缺乏稳定性.
- 由于混和研究设计,所有结果的证据确定性非常低.
结论:
- 口服家庭抗生素似乎不能减少儿科复杂尾炎的术后并发症.
- 由于缺乏益处和潜在危害,因此不支持常规使用.
- 需要高质量的前性研究来澄清真正的影响.
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