酒精使用障碍诊断和艾滋病毒预暴露 预防 坚持和继续:回顾性队列研究
Anton L V Avanceña1,2,3, Godwin Okoye4, Rishit Yokananth5
1Health Outcomes Division, College of Pharmacy, The University of Texas at Austin, 2409 University Ave, PHR 2.112, Austin, TX, 78712, USA. antonlv@utexas.edu.
Journal of general internal medicine
|January 27, 2026
概括
患有酒精使用障碍 (AUD) 的个人表现出较低的HIV暴露前预防 (PrEP) 的坚持和延续. 需要有针对性的干预措施来改善PrEP在这个人群中的使用.
科学领域:
- 公共卫生 公共卫生
- 临床药房 临床药房
- 传染病流行病学 传染病流行病学
背景情况:
- 酒精使用障碍 (AUD) 与艾滋病毒暴露前预防药物 (PrEP) 的遵守程度降低和中止有关.
- 这可能会损害PrEP在预防艾滋病毒传播方面的有效性.
研究的目的:
- 为了调查AUD和PREP的坚持和延续之间的联系.
- 为了确定与AUD的个体之间的PrEP使用的潜在差异.
主要方法:
- 使用MarketScan商业索赔数据进行回顾性队列研究.
- 包括在2014-2021年期间开始PrEP的16-64岁的个人,并持有持续保险.
- 在PREP启动前六个月内确定AUD诊断;依赖度以覆盖日数比例 (PDC) 衡量,并通过不间断供应继续.
主要成果:
- 在43,913人中,2.84%的人有先前存在的AUD诊断.
- 在一个匹配的样本中,AUD患者的PDC平均值明显较低 (59.54%vs65.85%) 和连续使用PrEP的日数较少 (107vs119.90天).
- 回归分析证实,AUD与平均PDC降低6.31%,PrEP持续时间减少12.93天有关.
结论:
- 预启动AUD与较差的PrEP坚持和继续有关.
- 这凸显了有针对性的干预措施的必要性,以支持在AUD患者中使用PrEP.
- 调查结果可能仅限于商业保险人群.
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