经过先前丸激素治疗的跨性别个体体体外受精结果
E S Rubin1, M Kornfield1, M Palmor1
1Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Oregon Health and Science University, Portland, OR, USA.
Human reproduction (Oxford, England)
|January 27, 2026
概括
变性人和性别多元的患者在之前接受过丸激素性别肯定激素治疗 (T-GAHT) 时,胚芽细胞的数量较少. 然而,成熟卵细胞的数量是相似的,大多数追求试管婴儿的患者都实现了活产.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 确认性别的护理
- 在体外受精过程中受精.
背景情况:
- 对于转性别和性别多样性 (TGD) 患者的胚胎结果的数据是有限的,他们之前接受过丸激素性别确认激素治疗 (T-GAHT).
- 之前的研究表明,T-GAHT后卵细胞产量很好,但胚胎细胞形成能力尚不清楚.
研究的目的:
- 为了调查T-GAHT之前的TGD患者与没有T-GAHT之前的患者相比,是否有不同的卵细胞冷保存和IVF结果.
- 评估T-GAHT对成熟卵细胞产量和胚胎细胞发育的影响.
主要方法:
- 从2013年1月到2024年3月,对TGD患者 (出生时被分配为女性) 进行了46次卵巢刺激周期的回顾性观察队列研究.
- 以往T-GAHT和没有T-GAHT的患者之间的结果比较,分析成熟的卵细胞和胚胎细胞形成.
- 用电子健康记录收集数据,对第一个完成的周期进行初级分析.
主要成果:
- 在调整年龄后,先前的T-GAHT与总芽细胞和高质量芽细胞的减少有关.
- 检测到的成熟卵细胞数量或成熟率没有显著差异.
- 第一个周期的累积活产率为之前的T-GAHT组的60%,而没有T-GAHT组的87.5%.
结论:
- 以前的T-GAHT与成熟卵细胞数量的差异无关,与现有文献保持一致.
- 较差的胚胎结局与先前的T-GAHT和更短的停药期有关.
- 大多数TGD患者在T-GAHT后接受体外受精,实现了活产,这表明生育结果总体上令人放心.
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