相关实验视频

Updated: Jan 29, 2026

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos
10:46

Rapid in vivo Drug Response Prediction Using Leukemia Cell Grafts in Zebrafish Embryos

Published on: May 23, 2025

932

PAM-CDR:具有财产意识的多模式药物表示学习,用于准确预测癌症药物反应

Yang Li, Chang Liu, Haijie Cui

    IEEE journal of biomedical and health informatics
    |January 27, 2026
    PubMed
    概括

    这项研究介绍了PAM-CDR,这是一个新的深度学习框架,通过整合药物特性和细胞系数据来预测癌症药物反应. PAM-CDR通过提高药物反应预测的准确性和可解释性来提高精确瘤学.

    更多相关视频

    Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients07:42

    Patient-Derived Tumor Explants As a "Live" Preclinical Platform for Predicting Drug Resistance in Patients

    Published on: February 7, 2021

    5.7K
    Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery09:38

    Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

    Published on: April 14, 2016

    13.1K

    相关概念视频

    Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs01:21

    Factors Affecting Drug Biotransformation: Physicochemical and Chemical Properties of Drugs

    A drug's physicochemical properties fundamentally influence its metabolism. For instance, a drug's molecular size and shape critically determine its interaction with enzymes and transporters — larger drugs may face difficulty reaching enzyme active sites, altering their metabolic pathways. The pKa of a drug, which establishes its ionization state, can impact its solubility and absorption, thereby influencing metabolism.
    The drug's acidity or basicity is essential in...
    750
    Factors Affecting Drug Response: Overview01:21

    Factors Affecting Drug Response: Overview

    When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
    3.0K
    Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

    Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

    Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
    The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
    363
    Pharmacokinetics: Drug–Drug Interactions01:25

    Pharmacokinetics: Drug–Drug Interactions

    Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
    430
    Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels01:31

    Factors Affecting Renal Clearance: Drug's Physicochemical Properties and Plasma Levels

    Renal clearance of a drug is influenced by various factors, including its physicochemical properties and plasma levels. These factors play a significant role in determining how efficiently the kidneys eliminate a drug.
    One important factor is the drug's molecular size. The kidneys readily excrete smaller molecules below 300 Daltons (Da). On the other hand, molecules weighing between 300 and 500 Da are excreted through both urine and bile. Larger molecules above 500 Da tend to be excreted...
    593
    Self-Awareness and Its Effects01:21

    Self-Awareness and Its Effects

    Self-awareness is a psychological state in which the individual becomes the focal point of their attention. This inward focus transforms the self into an object of contemplation and assessment, influencing how individuals perceive their actions and their alignment with personal and societal standards.Triggers and Contexts for Self-AwarenessSelf-awareness can be activated by external stimuli that make individuals visually or audibly aware of themselves, such as mirrors, cameras, or recordings.
    308