哺乳动物的泛表观遗传年龄预测
Zane Koch1, Adam Li1, Trey Ideker1,2,3
1Program in Bioinformatics and Systems Biology, University of California San Diego, La Jolla, California, USA.
Aging cell
|January 27, 2026
概括
表观遗传重塑,包括基因组修饰和DNA甲基化,在多种组织中显示了与衰老协调的变化. 从这些变化中发展起来的表观遗传时钟准确地预测了人类和小鼠的生物年龄.
科学领域:
- 表观遗传学和衰老研究.
- 衰老的分子生物学
- 进行比较的基因组学.
背景情况:
- 表观遗传改变是衰老过程的关键特征.
- 在衰老过程中不同表观遗传层 (例如,基因质标记,DNA甲基化) 之间的相互作用尚未完全理解.
- 需要对多种组织和物种进行全面的分析来阐明这些关系.
研究的目的:
- 综合分析跨多个表观遗传层 (基因组标记和DNA甲基化) 的与年龄有关的变化.
- 研究老化过程中不同表观遗传修饰之间的相互关系.
- 开发和验证生物年龄的预测性表观遗传钟.
主要方法:
- 在1000多名人类和小鼠的12个组织中分析了6个基因组标记和DNA甲基化.
- 基于通过同步表观遗传变化识别的基因开发表观遗传钟.
- 使用斯皮尔曼相关性验证时钟的预测准确度.
主要成果:
- 在基因组修饰和DNA甲基化之间观察到与年龄相关的表观遗传变化的同步模式.
- 这些协调的变化汇聚在一组共同的基因上.
- 来自这些基因的表观遗传钟准确地预测了不同表观遗传层的年龄 (斯皮尔曼p:0.70在人类中,0.81在小鼠中).
- 基因组蛋白修饰和DNA甲基化档案一致预测了个体的衰老速度.
结论:
- 表观遗传修饰在整个生命周期中经历协调重塑.
- 这种协调的改造为表观遗传衰老提供了统一的视角.
- 这些发现支持对表观遗传衰老的整体观点,表观遗传衰老受多种相互关联的分子机制的影响.
相关概念视频
01:46Epigenetic Regulation
33.7K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.7K
01:37Epigenetic Regulation
3.9K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.9K
02:27Predicting Molecular Geometry
45.7K
VSEPR Theory for Determination of Electron Pair Geometries
45.7K
01:26Aging
673
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
673
01:03Prediction Intervals
3.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.
3.4K
01:19The Effect of Aging on Tissues
3.5K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.5K