相关实验视频
Updated: Jan 29, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
Published on: July 7, 2014
蛋白质组学分析揭示了六价通过氧化应激对BEAS-2B细胞的损害机制
Lei Liu1,2, Panpan Guo1, Mingxia Zhang1
1Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health & Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
六价 (U(VI)) 暴露会改变肺细胞蛋白质组,增加氧化应激,影响细胞循环和信号通路. 这项研究揭示了U(VI对肺上皮细胞的分子作用.
科学领域:
- 环境毒理学环境毒理学
- 蛋白质组学是指蛋白质组学
- 细胞生物学 细胞生物学
背景情况:
- 六价 (U(VI)) 是一种环境污染物,已知对人类肺部健康产生影响.
- 了解 (VI) 毒性的分子机制对于评估健康风险至关重要.
研究的目的:
- 为了研究暴露于U(VI) 的肺上皮细胞中的蛋白质组变化.
- 阐明涉及U(VI) 诱导的肺细胞毒性分子途径.
主要方法:
- 利用数据独立获取 (DIA) 蛋白质组学来分析BEAS-2B细胞中的差异性蛋白质表达.
- 细胞暴露在不同度的U ((VI) (0, 200, 400, 700 mg/L) 中24小时.
- 进行了KEGG和GO丰富分析,测量了氧化应激标志物 (ROS,GSH),并验证了关键蛋白表达.
主要成果:
- U(VI) 暴露导致差异表达蛋白 (DEP) 的剂量依赖性增加.
- 丰富的通路包括PI3K-Akt信号传递,癌症通路,细胞周期,溶酶体和JAK-STAT信号传递.
- 观察到ROS水平增加,GSH减少,以及参与细胞循环,转录和细胞迁移的蛋白质的表达改变.
结论:
- U(VI) 在肺上皮细胞中诱导显著的蛋白质变化,影响关键的细胞过程.
- 氧化应激在U (VI) 毒性中起着关键作用.
- 这项研究提供了U(VI) 诱导的肺损伤的分子基础的见解.
更多相关视频
09:23Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
Published on: June 21, 2015
07:35Laser Microdissection-Based Protocol for the LC-MS/MS Analysis of the Proteomic Profile of Neuromelanin Granules
Published on: December 16, 2021
相关概念视频
Oxidation Numbers
DNA Damage Can Stall the Cell Cycle
DNA Damage can Stall the Cell Cycle
Proteomics
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Pyruvate Oxidation
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
Design of Transmission Shafts - Stress Analysis