细胞癌诊断的进步:对生物标志物的审查
概括
准确的细胞癌 (RCC) 诊断需要整合形态学,免疫组织化学 (IHC) 和分子测试. 先进的分子分析和液体活检对于分类新型的RCC亚型和指导个性化治疗策略至关重要.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 遗传学 是一个
背景情况:
- 细胞癌 (RCC) 是一种复杂的疾病,具有新的分子定义的亚型.
- 准确的分类需要整合形态学,免疫组织化学 (IHC) 和分子技术,以减少"其他未指定的RCC (NOS) "类别.
研究的目的:
- 突出结合组织病理学,IHC和分子测试的必要性,以准确诊断RCC.
- 讨论先进的分子分析和新兴的液体活检生物标志物在RCC管理中的作用.
主要方法:
- 利用免疫组织化学 (IHC) 作为分子改变的替代品.
- 采用像下一代测序 (NGS) 和光在位杂交 (FISH) 这样的分子分析.
- 研究液体活检工具的潜力,包括循环微RNA,ctDNA甲基化和循环瘤细胞 (CTC).
主要成果:
- IHC对于诊断既定和新型RCC实体至关重要,作为特定分子变化的替代品.
- 分子测定 (NGS,FISH) 对于诊断分子定义的RCC是必不可少的,一些实体如ELOC突变的RCC需要分子测试.
- 液体活检组件,如循环的microRNAs,ctDNA和CTCs,对RCC诊断,分类,监测和分层有很大的希望.
结论:
- 精确的RCC诊断整合组织病理学,IHC和分子测试对于管理,遗传综合征识别和个性化治疗至关重要.
- 不断发展的分子诊断和循环生物标志物需要仔细的临床整合,以优化患者的治疗结果.
- 传统方法与新型分子和液体活检方法的结合提高了RCC分类和治疗策略的精度.
更多相关视频
05:36Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
9.5K
06:38A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
14.2K
相关概念视频
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
Nursing Diagnosis
4.0K
Following assessment, a nursing diagnosis is the next step in the nursing process. It begins after the nurse has collected and recorded the patient data. The purpose of diagnosing is to identify how the client responds to actual or potential health processes, identify factors that bestow or that cause health problems, the etiologies, and identify resources or strengths the individual, group, or community can draw on to prevent or resolve problems.
The nursing diagnosis focuses on evidence-based...
The nursing diagnosis focuses on evidence-based...
4.0K
Factors Affecting Renal Clearance: Renal Impairment
454
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
454
Overview of Advanced Functional Groups
29.7K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.7K
Renal Corpuscle
7.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
7.3K
