移植药物及其对骨科手术中伤口愈合的影响
Sonia E Ubong1, Santiago A Lozano-Calderon
1From the Division of Orthopaedic Oncology, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
The Journal of the American Academy of Orthopaedic Surgeons
|January 27, 2026
概括
移植药物会损害骨科患者的伤口愈合,增加并发症风险. 本综述提供基于证据的术后管理策略,以优化这些高风险个体的外科治疗结果.
科学领域:
- 整形外科手术 整形外科手术
- 免疫抑制是一种免疫抑制.
- 伤口愈合生物学 伤口愈合生物学
背景情况:
- 移植药物对于患有自身免疫性疾病,恶性瘤和固体器官移植的患者至关重要.
- 免疫抑制患者患有骨 necrosis,骨折和退行性关节疾病的风险增加,需要骨科干预.
- 这些药物会影响免疫功能和伤口愈合,导致感染和植入物失败等并发症的发生率更高.
研究的目的:
- 系统地审查移植药物如何干扰组织修复机制.
- 为接受整形外科手术的免疫抑制患者提供基于证据的建议,用于术后药物调整.
- 为了优化手术结果,并最大限度地减少这种高风险人群的并发症.
主要方法:
- 系统的文献审查.
- 检查移植药物对伤口愈合的生理干扰.
- 对外科手术期间管理策略的分析.
主要成果:
- 移植药物抑制炎症反应,原合成,血管生成和细胞增殖.
- 这种干扰增加了手术部位感染,伤口脱光,延迟结合和植入物失败的风险.
- 免疫抑制患者的恶性瘤发病率较高使管理复杂化.
结论:
- 对免疫抑制移植患者的术后伤口愈合管理的全面指导是零碎的.
- 需要基于证据的建议来优化药物调整和手术结果.
- 优化术后管理对于减轻并发症和改善功能结果至关重要.
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