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Updated: Jan 29, 2026

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来自分子动力学模拟和冷EM的α7 nAChR中epibatidine与脱敏门的结合证据

Jesko Kaiser1, Christoph G W Gertzen1,2, Daniel Mann3

  • 1Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, 40225 Düsseldorf, Germany.

Journal of chemical information and modeling
|January 27, 2026
PubMed
概括

阿尔法7-尼古丁性乙胆受体 (nAChR) 有一个新发现的结合部位. 分子动力学模拟显示,epibatidine可以在受体孔内结合,而不仅仅是活性部位.

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