树叶化物及其主要成分1-脱氧尼吉利米通过PI3K/AKT/mTOR途径促进自,减轻CDAHFD诱导的代谢功能障碍相关的胆固醇肝炎
Chen Yang1, Feng Xiang1, Zhiqiang He1
1Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Journal of agricultural and food chemistry
|January 27, 2026
概括
摩尔叶化物 (MLA),包括1-deoxynojirimycin (DNJ),通过减少肝损伤和纤维化来预防脂肪肝疾病 (MASH). DNJ通过PI3K/AKT/mTOR途径促进自,提供治疗潜力.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 树叶化物 (MLA) 在调节肝脂代谢,氧化应激和炎症方面表现有前途.
- 1-deoxynojirimycin (DNJ) 是木叶中的一个关键化物,具有多种生物活性.
- 非酒精性脂肪肝炎 (MASH) 是一个越来越严重的问题,治疗选择有限.
研究的目的:
- 在小鼠中研究MLA和DNJ对MASH的肝保护作用.
- 阐明潜在的机制,重点关注PI3K/AKT/mTOR通路和自.
主要方法:
- 使用缺乏胆,L-氨基酸定义,高脂肪饮食 (CDAHFD) 来诱导小鼠的MASH.
- 用MLA和DNJ来评估它们对肝脏病理,脂肪,炎症和纤维化的影响.
- 研究PI3K/AKT/mTOR通路和与自相关的蛋白质表达.
- 进行了分子对接和动力学模拟,以评估DNJ与关键蛋白质的相互作用.
主要成果:
- 在MASH小鼠中,MLA和DNJ显著改善了肝损伤,肥胖症,炎症和纤维化.
- 治疗抑制了PI3K/AKT/mTOR通路,并增加了与自有关的蛋白质的表达.
- 在中,DNJ与PI3K,AKT和mTOR表现出良好的结合亲和力.
结论:
- 通过调节PI3K/AKT/mTOR通路,DNJ促进了自.
- 这种机制有助于缓解MASH症状和肝纤维化.
- 树叶化物,特别是DNJ,代表了MASH的潜在治疗策略.
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