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Updated: Jan 29, 2026

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评估Boltz-2性能,用于对接撞击的约束性分类

Guillaume Bret1, François Sindt1, Didier Rognan1

  • 1Laboratoire d'innovation thérapeutique, UMR7200 CNRS-Université de Strasbourg, F-67400 Illkirch, France.

Journal of chemical information and modeling
|January 27, 2026
PubMed
概括

博尔茨-2共折叠模型在预测蛋白质-连接体结构和结合亲缘关系方面表现有前途. 然而,它的亲和力预测可能依赖于隐藏的特征而不是真正的物理,这引发了对药物发现应用的担忧.

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