从榴皮中电化学提取的纳米纤维素作为迪克洛芬雅克输送的生物相容载体
Ngoc Yen Nguyen1, Chi Dien Duong2, Hau Danh2
1Applied Chemical Engineering Laboratory, Can Tho University, 3/2 street, Ninh Kieu, Can Tho, 94000, Viet Nam; Department of Health Sciences, College of Natural Sciences, Can Tho University, 3/2 street, Ninh Kieu, Can Tho, 94000, Viet Nam.
International journal of biological macromolecules
|January 27, 2026
概括
这项研究使用绿色电解从榴莲皮废物中开发出生物相容的纳米纤维素载体. 这些纳米纤维素颗粒显示出控制药物输送系统的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 化学工程是化学工程的重要组成部分.
背景情况:
- 榴莲皮是东南亚丰富的农业废物.
- 用于制药应用的树脂纤维素生物质的利用对于可持续性至关重要.
- 纳米纤维素为药物输送系统提供独特的特性.
研究的目的:
- 开发一种可持续和绿色的方法,从榴皮中提取纳米纤维素.
- 描述产生的纳米纤维素及其适用于药物输送的特性.
- 评估药物吸附和释放动力学,以及纳米纤维素载体的生物相容性.
主要方法:
- 绿色电解辅助从榴莲皮中提取纤维素.
- 使用响应表面方法来优化提取.
- 酸水解和超声波制造以产生纤维素纳米粒子 (CNPs).
- 描述CNP的特性 (晶度,热稳定性,表面积,粒子大小,表面电荷).
- 使用迪克洛菲纳克 (DCF) 进行吸附研究,以确定动力学和异温物.
- 在模拟生理介质中的体外药物释放研究.
- 生物相容性评估 (血液溶解,HET-CAM测定,粘膜粘合).
主要成果:
- 优化的绿色电解产生了具有高晶度 (61.2%) 和热稳定的纤维素.
- 纤维素纳米粒子 (CNPs,100-300nm) 已经成功地产生了稳定的表面电荷.
- 随着DCF吸附,出现了伪二次动力学和弗洛伊德利希/杜比宁-拉杜什凯维奇等热量.
- 药物释放表明持续和pH响应的行为.
- CNPs表现出极好的生物相容性 (低血解,无刺激性) 和强大的粘膜粘附性.
结论:
- 建立了一个可扩展和环保的战略,用于从榴莲皮废物中生产生物相容的纳米纤维素载体.
- 开发的CNP是可控口服和肠道药物输送系统的有希望的候选者.
- 这种利用方法有助于可持续的废物管理和制药创新.
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