肠道病毒感染是由宿主细胞中微和纳米颗粒的积累促进的
Yihan Wang1, Boya Xiong2, Jun Lyu3
1Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, United States; Department of Civil and Environmental Engineering, The George Washington University, Washington, DC 20052, United States.
Journal of hazardous materials
|January 27, 2026
概括
微型和纳米塑料 (MNP) 通过释放更多传染性病毒颗粒和削弱免疫系统来促进病毒传播. 这项研究揭示了与塑料污染和病毒感染相关的新健康风险.
科学领域:
- 环境科学 环境科学
- 病毒学 病毒学
- 毒理学 毒理学 毒理学
背景情况:
- 微型和纳米塑料 (MNP) 是普遍存在的环境污染物.
- 对于MNP对病毒感染的影响在很大程度上是未知的.
- 许多MNP可以在人体中积累.
研究的目的:
- 研究基于聚烯的MNP (MNP-PS) 对病毒感染的影响.
- 阐明MNP介导病毒传播的潜在机制.
- 评估细胞外囊泡 (EVs) 在这个过程中的作用.
主要方法:
- 暴露RAW 264.7巨细胞对MNP-PS和小鼠诺罗病毒 (MNV-1).
- 分析EV释放和病毒囊泡的特征.
- 测量免疫细胞因子表达 (TNF-α,IL-6,IFN-β).
主要成果:
- 预暴露MNP-PS显著增强病毒感染.
- 裸体MNP-PS刺激了更多传染性病毒EVs的释放.
- MNP-PS降低了关键的先天性免疫细胞因子表达的调节,损害了抗病毒防御.
结论:
- 通过EV介导的机制,MNP促进病毒传播.
- 暴露于MNP会带来以前未知的健康风险.
- 塑料污染可能成为病毒传播和疾病进展的辅助因素.
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