BCG疫苗对新生儿系统性炎症的影响
Valerie A C M Koeken1, Thomas N Nissen2, Nina M Birk3
1Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Computational Biology for Individualised Infection Medicine, Centre for Individualised Infection Medicine (CiiM), A Joint Venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; TWINCORE, A Joint Venture between the Helmholtz-Centre for Infection Research (HZI) and the Hannover Medical School (MHH), Hannover, Germany; Research Centre Innovations in Care, Rotterdam University of Applied Sciences, Rotterdam, the Netherlands.
疫苗接种Bacillus Calmette-Guérin (BCG) 疫苗暂时减少了新生儿的全身炎症,特别是在女孩身上. 这种效应随着时间的推移而减弱,突出显示了BCG在生命早期对性别特异性免疫调节的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 新生儿健康 新生儿健康
- 疫苗学 疫苗学 疫苗学
背景情况:
- 新生儿的全身炎症可能会对长期健康产生影响.
- 卡尔梅特-盖林杆菌 (BCG) 疫苗是已知具有免疫调节作用的广泛使用的疫苗.
- 越来越多地认识到免疫反应的性别特异性差异.
研究的目的:
- 评估BCG疫苗接种对新生儿系统性炎症的影响.
- 为了研究BCG抗炎作用的性别特异性差异.
- 探索炎症蛋白,细胞因子生产和BCG疫苗接种后抗体水平之间的关系.
主要方法:
- 一项随机临床试验,涉及BCG疫苗接种和未接种新生儿.
- 用近距离延伸试验测量了92种血炎性蛋白质,测量时间为4天,3个月和13个月.
- 分析炎症标记物的变化及其与免疫标记物的关联.
主要成果:
- 女孩表现出比男孩更高的基线炎症标志物.
- 接种BCG疫苗导致系统性炎症的适度降低,在3个月的女孩中最明显.
- BCG的抗炎作用是短暂的,在接种疫苗后13个月没有可测量的效果.
- 接种BCG疫苗改变了炎症蛋白和免疫反应之间的关联.
结论:
- 接种BCG疫苗可能会暂时减少新生儿的全身炎症,在女孩身上效果更强.
- 研究结果表明,BCG的抑制炎症效应在具有较高基线炎症水平的个体中更为明显.
- 接种BCG疫苗以时间依赖的方式调节循环炎症蛋白质,并影响炎症标志物-免疫功能关联,强调性别特异和个性化接种策略.
更多相关视频
08:10A Functional Whole Blood Assay to Measure Viability of Mycobacteria, using Reporter-Gene Tagged BCG or M.Tb BCG lux/M.Tb lux
Published on: September 14, 2011
06:32Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
相关概念视频
Vaccinations
Inflammation
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Second Order systems II
First Order Systems
When a first-order system is subjected to a unit-step input, its response is characterized by its transfer function. By applying the Laplace transform of the unit-step input to the transfer function, expanding the...
Second Order systems I
By reinterpreting the system, one can derive the closed-loop transfer function, which...
