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作为hCA IX抑制剂的triazinyl-benzenesulfonamide衍生物:使用优化的停止流方法设计,合成和活性确定

Vojtech Varecka1, Karolina Seligova2, Alena Hofrova3

  • 1Department of Chemistry, Faculty of Science, Masaryk University, Kotlarska 2, 611 37 Brno, Czech Republic.

Bioorganic chemistry
|January 27, 2026
PubMed
概括

研究人员开发了新的1,3,5-triazinyl-benzenesulfonamide衍生物,作为人类碳酸无水酶IX (CA IX) 的强有力的抑制剂. 这些化合物对与癌症相关的CA IX具有有前途的选择性和活性,表现优于乙胺.

关键词:
一,三,五-三氨酸芳香替代是一种芳香替代.二硫胺胺的使用方法碳酸无水酶是一种碳酸无水酶.酶抑制可以抑制酶.异酶选择性的选择性停止的流量光谱光度计.

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