瘤生态系统:重新连接一个开放的,系统集成的网络,以获得治疗效益
Paola Chiodelli1, Andrea Papait1, Lorenzo Agoni2
1Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome 00168, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|January 27, 2026
概括
瘤微环境 (TME) 是一个开放的生态系统,不是孤立的. 肠道微生物群等系统因素影响癌症疗法,需要新的生态方法来治疗成功.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 系统生物学 系统生物学
背景情况:
- 瘤微环境 (TME) 是一个关键的治疗点,但TME向药物的临床转化滞后.
- 目前对TME作为一个独立的实体的减少主义观点无法解释治疗阻力.
研究的目的:
- 为理解TME作为一个开放的,多层次的生态系统提出一个新的框架.
- 整合塑造TME并影响治疗结果的局部和系统因素.
主要方法:
- 概念框架的发展.
- 整合现有关于局部TME组件 (CAFs,骨髓细胞,血管系统) 和系统因素 (肠道微生物组,炎症) 的知识.
主要成果:
- TME是由系统性宿主因素动态塑造的.
- 局部组件形成集成的功能,协调关键的癌症过程.
- 系统因素,如肠道微生物组和炎症预先条件宿主和调节治疗.
结论:
- 治疗耐药性是TME作为一个开放系统的生态适应.
- 下一代疗法需要空间奥米克和多式模式策略,将TME视为一个系统集成的网络.
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