用集群电极进行不可逆向电穿孔的前景评估,作为局部高级胰腺癌的新缓解方法
Joon Ho Kwon1, Man-Deuk Kim2, Maher Salamah Alanazi1,3
1Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
Korean journal of radiology
|January 27, 2026
概括
使用集群电极的不可逆电穿孔 (IRE) 显示出局部晚期胰腺癌 (LAPC) 的前景,在试点研究中证明了可行性,安全性和令人鼓舞的生存结果.
科学领域:
- 在瘤学瘤学.
- 干预性放射学 干预性放射学
- 手术瘤学手术瘤学
背景情况:
- 局部晚期胰腺癌 (LAPC) 存在重大治疗挑战.
- 最少侵入性的治疗选择对于改善患者的治疗结果至关重要.
研究的目的:
- 在LAPC患者中使用集群电极技术评估不可逆电穿孔 (IRE) 的可行性,安全性和瘤结果.
- 评估IRE后的技术成功,并发症率,整体存活率 (OS) 和无进展存活率 (PFS).
主要方法:
- 一个单一中心前性队列研究,涉及13名LAPC患者.
- 患者接受了集群电极IRE (手术内或皮肤间).
- 收集的数据包括程序细节,并发症,操作系统和PFS.
主要成果:
- 在所有患者中都取得了技术上的成功.
- 两名患者 (15.4%) 经历了胃肠道出血,并通过栓塞成功治疗. 没有60天死亡率.
- 平均OS和PFS分别为20.1个月和14.5个月,平均随访时间为24.5个月.
结论:
- 使用集群电极的不可逆电穿孔 (IRE) 是LAPC的可行和安全的方法.
- 该技术证明了可靠的技术成功和令人鼓舞的生存数据.
- 需要进行更大规模的受控研究来进一步验证这些发现.
更多相关视频
03:55Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
967
07:55Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
1.8K
相关概念视频
Reversible and Irreversible Processes
5.8K
The thermodynamic processes can be classified into reversible and irreversible processes. The processes that can be restored to their initial state are called reversible processes. It is only possible if the process is in quasi-static equilibrium, i.e., it takes place in infinitesimally small steps, and the system remains at equilibrium However, these are ideal processes and do not occur naturally. An ideal system undergoing a reversible process is always in thermodynamic equilibrium within...
5.8K
Standard Electrode Potentials
50.1K
On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
50.1K
Cluster Sampling Method
14.5K
Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
To choose a cluster sample, divide the population into clusters (groups) and then randomly select some of the clusters. All the members from these clusters are in the cluster sample. For example, if you randomly sample four departments from your...
14.5K
Vesicular Tubular Clusters
3.2K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
With the help of motor proteins such...
3.2K
Overview of Advanced Functional Groups
29.7K
Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
29.7K
Electrodes: Overview
2.7K
Electrochemical measurements are conducted in an electrochemical cell composed of various components that control and measure the current and potential. One fundamental component is electrodes, conductive materials that enable electron transfer reactions at their surfaces.
There are two main types of electrodes in electrochemical cells. The first type, known as the working or indicator electrode, has a potential that is sensitive to the analyte's concentration and reacts to changes in...
There are two main types of electrodes in electrochemical cells. The first type, known as the working or indicator electrode, has a potential that is sensitive to the analyte's concentration and reacts to changes in...
2.7K
