在COVID-19后长期肺功能和放射性异常,长达3年:系统性审查和元分析
Jiyoung Song1, Jong Hyuk Lee1, Hyungin Park2
1Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
Korean journal of radiology
|January 27, 2026
概括
COVID-19幸存者在肺功能和CT扫描中呈现逐渐改善,长达3年的时间. 然而,持续扩散能力 (DLCO) 损害和稳定的肺纤维化仍然对长期康复存在担忧.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 长期的COVID可能会导致持续的呼吸系统问题.
- 了解长期肺部恢复轨迹对于患者管理至关重要.
研究的目的:
- 系统地评估COVID-19幸存者长期肺功能测试 (PFT) 和CT发现,感染后长达36个月.
主要方法:
- 在PubMed和EMBASE的系统文献搜索 (2020年1月至2024年6月).
- 包括在COVID-19后≥6个月报告PFT和/或胸部CT结果的研究.
- 多变量元分析以评估肺功能和放射性异常的时间趋势.
主要成果:
- 扩散能力 (DLCO) 的损害从6个月后的42%提高到36个月后的35%.
- 随着时间的推移,强迫性生命能力 (FVC) 损伤减少.
- 地面玻璃的不透明度 (GGO) 从32%降至20%,而纤维化仍然普遍存在 (27%-47%),没有显著变化.
结论:
- 肺功能 (DLCO,FVC) 和GGO的发现显示了长达3年的逐步改善.
- 超过三分之一的患者表现出持续的DLCO损伤.
- 肺纤维化仍然稳定,这表明大多数幸存者的非进展模式.
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