一种针对艾滋病相关的非霍奇金淋巴瘤的益免疫毒素纳米药物
Shilin Chen1, Tong Qi1, Hongxu Peng2
1Department of Microbiology, Immunology, and Molecular Genetics, Geffen School of Medicine, University of California Los Angeles (UCLA), Los Angeles, CA, USA; UCLA AIDS Institute, Los Angeles, CA, USA; Department of Chemical and Biomolecular Engineering, UCLA, Los Angeles, CA, USA.
概括
一种新型纳米药物,n(ch128.1Av/b-SO6) -CXCL13,通过向瘤细胞提供免疫毒素,有效准并治疗与艾滋病相关的非霍奇金淋巴瘤 (艾滋病-NHL). 这一突破最大限度地降低了毒性,并显示出其他癌症的前景.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 纳米技术纳米技术
背景情况:
- B细胞非霍奇金淋巴瘤 (NHL) 是一种流行癌症,在艾滋病毒感染个体中特别具有攻击性,导致艾滋病相关NHL (AIDS-NHL).
- 转激素受体1 (TfR1/CD71) 在NHL细胞上过度表达,呈现出一种可行的治疗标.
- 现有的免疫毒素如ch128.1Av/b-SO6显示有效性,但遭受全身毒性.
研究的目的:
- 开发一个有针对性的药物输送系统,以克服艾滋病-NHL系统性免疫毒素的局限性.
- 创建一种亲免疫毒素纳米药物,该药物在瘤微环境中专门释放它的有效载荷,减少非目标效应.
主要方法:
- 开发一种亲免疫毒素纳米药物,n(ch128.1Av/b-SO6) -CXCL13,在聚合物外中封装免疫毒素.
- 纳米药物的稳定使用金属蛋白酶-2 (MMP-2) 响应性交联结剂和与B细胞向化学激素CXCL13的结合.
- 在与艾滋病相关的NHL异种移植小鼠模型中评估纳米药物的疗效和安全性.
主要成果:
- 这种纳米药物在瘤微环境中表现出免疫毒素的特定积累和释放,由MMP-2介导.
- 由于与胆载体的相互作用,观察到增强的组织透.
- 在艾滋病-NHL异种移植模型中实现了显著的抗瘤疗效,系统毒性降至最低.
结论:
- 益免疫毒素纳米药物n(ch128.1Av/b-SO6)-CXCL13为艾滋病-NHL的向治疗提供了一个有前途的战略.
- 这种方法有可能通过利用瘤特异性酶和向部分来适应治疗其他恶性瘤.
相关概念视频
Targeted Cancer Therapies
8.9K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.9K
Targets for Drug Action: Overview
10.2K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.2K
Target Cell Response to Hormones
5.7K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
5.7K
Regulated mRNA Transport
7.0K
In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
7.0K
Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Fruit Development, Structure, and Function
25.2K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.2K


