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Updated: Jan 29, 2026

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制药热挤出过程的流程优化:通过SIFT-MS实时检测挥发物,并与多变量分析相结合

Aaron D Smith1, Ecaterina Bordos1, Michael Devlin1

  • 1CMAC, University of Strathclyde, Technology and Innovation Centre, Glasgow, United Kingdom; Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom.

International journal of pharmaceutics
|January 27, 2026
PubMed
概括

选择性离子流管质谱学 (SIFT-MS) 精确地定义了用于热挤出 (HME) 的制药聚合物加工窗口. 这种方法可以检测早期的化学变化,从而实现优化无形固体分散制造.

关键词:
无形固体分散的分散.热挤出方法 热挤出方法在PCA中,PCA是PCA.这就是SIFT-MS.挥发性分析 挥发性分析

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