在怀孕前和怀孕期间在小鼠中进行蛋白质限制后的胎盘形态功能适应和后代结果
Fernando Felicioni1, José Andrés Nivia-Riveros1, Andre Lucas Caldeira-Brant2
1Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Av. Antônio Carlos, 6627, 31270-901, Belo Horizonte, MG, Brazil.
The Journal of nutritional biochemistry
|January 27, 2026
概括
母亲的低蛋白饮食会改变胎盘结构和基因表达,导致胎儿生长受损,特别是在男性中. 这些适应部分补偿,但不能完全防止发展问题.
科学领域:
- 生殖生物学 生殖生物学
- 发展规划是指发展规划.
- 母胎营养 母胎营养
背景情况:
- 孕产妇的营养对胎儿发育至关重要.
- 低蛋白饮食可能会影响怀孕的结果.
- 胎盘适应是营养转移的关键.
研究的目的:
- 为了研究胎盘的形态功能适应低蛋白饮食 (LPD).
- 评估LPD对胎儿和新生儿结局的影响.
- 探索特定区域的胎盘基因表达变化.
主要方法:
- 在怀孕前和怀孕期间,瑞士小鼠被食正常 (NPD) 或低蛋白饮食 (LPD).
- 胎盘形态,基因表达和胎儿/新生儿生物识别在特定的妊娠日和出生时被分析.
- 进行了定量PCR和组织学分析.
主要成果:
- 在LPD的胎盘中显示出改变了母亲的鼻状和胎儿血管的比例.
- 在LPD胎盘中观察到特定区域的基因表达变化 (例如Fatp4,Mtor,Kiss1,Stat3,Snat1,Igf2r).
- 在LPD胎儿和新生儿中,体重较低,脑肝比较高,尤其是男性.
结论:
- 母亲的LPD诱导特定区域的胎盘适应,部分补偿营养限制.
- 尽管有适应性,但LPD会损害胎儿的生长和发育,对男性后代产生不成比例的影响.
- 这些发现突出了母亲营养,胎盘功能和胎儿编程之间的复杂相互作用.
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