相关实验视频
Updated: Jan 29, 2026

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Acute Brain Trauma in Mice Followed By Longitudinal Two-photon Imaging
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慢性疼痛中的心理创伤与大脑相关:一个系统性审查
Tong En Lim1, Eilish Fitzpatrick2, Saurab Sharma3
1NeuroRecovery Research Hub, School of Psychology, The University of New South Wales (UNSW) Sydney, Sydney, NSW, Australia; Centre for Pain IMPACT, Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia.
Neuroscience and biobehavioral reviews
|January 27, 2026
概括
儿童或成年期的创伤暴露与慢性疼痛成年人的大脑变化有关. 这些大脑结构和功能的改变可能表明创伤后的未来慢性疼痛发展.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 疼痛研究 疼痛研究
背景情况:
- 创伤事件是发展和维持慢性疼痛的重要危险因素.
- 慢性疼痛和创伤都与类似的大脑变化和认知缺陷有关.
- 在慢性疼痛患者中,与创伤暴露相关的特定大脑变化尚不清楚.
研究的目的:
- 为了研究与慢性疼痛成年人的创伤暴露相关的大脑变化.
- 在慢性疼痛群体中识别受童年和成人创伤影响的特定大脑区域和网络.
主要方法:
- 在三个电子数据库中进行了系统的文献搜索.
- 包括对患有慢性疼痛的成年人进行的观察性研究,以及与创伤暴露有关的报告的大脑变化.
- 数据提取和偏差风险评估由独立审稿人进行.
主要成果:
- 儿童时期的逆境与前带皮质,海马体,胰岛和突出网络的改变有关.
- 成年期的创伤暴露与海马,胰岛,环状皮质和上回形的变化有关.
- 慢性疼痛患者的创伤暴露与记忆,语言和整体认知功能受损有关.
结论:
- 有证据表明,创伤暴露会导致慢性疼痛患者的大脑发生变化.
- 异常突出和默认模式网络活动可能作为创伤后慢性疼痛发展的标志物.
- 网络集中和情绪向的干预措施显示出治疗创伤暴露个体的慢性疼痛的潜力.
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