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相关概念视频

Fermentation01:29

Fermentation

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Most eukaryotic organisms require oxygen to survive and function adequately. Such organisms produce large amounts of energy during aerobic respiration by metabolizing glucose and oxygen into carbon dioxide and water. However, most eukaryotes can generate some energy in the absence of oxygen by anaerobic metabolism.
Fermentation is a type of metabolic process that occurs in the absence of oxygen, where organic molecules such as glucose are broken down to produce energy. During this process, the...
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Microbial Fermentation01:23

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Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
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Nucleic Acids02:43

Nucleic Acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Weak Acid Solutions04:02

Weak Acid Solutions

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Few compounds act as strong acids. A far greater number of compounds behave as weak acids and only partially react with water, leaving a large majority of dissolved molecules in their original form and generating a relatively small amount of hydronium ions. Weak acids are commonly encountered in nature, being the substances partly responsible for the tangy taste of citrus fruits, the stinging sensation of insect bites, and the unpleasant smells associated with body odor. A familiar example of a...
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Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

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Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
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Ions as Acids and Bases02:54

Ions as Acids and Bases

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Salts with Acidic Ions
Salts are ionic compounds composed of cations and anions, either of which may be capable of undergoing an acid or base ionization reaction with water. Aqueous salt solutions, therefore, may be acidic, basic, or neutral, depending on the relative acid-base strengths of the salt’s constituent ions. For example, dissolving the ammonium chloride in water results in its dissociation, as described by the equation:
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相关实验视频

Updated: Jan 29, 2026

Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids
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从发酵中通过新型下游加工回收3-基酸:技术经济分析.

Chandan Mahata1, Somesh Mishra1, Vijay Singh1

  • 1Department of Agricultural and Biological Engineering, The Grainger College of Engineering, University of Illinois at Urbana-Champaign, IL-61801, USA; DOE Center for Advanced Bioenergy and Bioproducts Innovation, University of Illinois Urbana Champaign, USA.

Bioresource technology
|January 27, 2026
PubMed
概括

一个新的,无溶剂的下游加工策略有效地从发酵中回收高纯度的3-基酸 (3-HP). 这种可扩展的方法可以产生固体盐和缩溶液,证明生物烯酸生产的成本具有竞争力.

关键词:
3 - 基烯酸是3 - 基烯酸中的一种吸附方式 吸附方式 吸附方式下游处理 (DSP)灵敏度分析是一种灵敏度分析.技术经济分析 (TEA)

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科学领域:

  • 生物化学工程 生物化学工程
  • 分离科学 分离科学
  • 绿色化学 绿色化学

背景情况:

  • 3-基酸 (3-HP) 是一种重要的生物基平台化学物质.
  • 有效和成本效益的下游加工 (DSP) 对于工业3HP生产至关重要.
  • 目前的DSP方法往往涉及溶剂,并且耗费大量能量.

研究的目的:

  • 开发和验证一个简化的,完全没有溶剂的DSP战略,用于高纯度的3HP回收.
  • 为了证明3-HP作为固体盐和缩水溶液的综合回收.
  • 评估生物烯酸生产开发的DSP工艺的经济可行性.

主要方法:

  • 优化活性炭处理以进行脱色 (98%的色彩去除).
  • 离子交换色谱使用Amberlite IRA-67在pH 4.5和30°C.
  • 集成的无溶剂DSP,包括盐沉和溶液度.
  • 技术经济分析以确定最低销售价格.

主要成果:

  • 在实验室尺度上获得了77.3%的3-HP回收,纯度为83.2%.
  • 生产了30% (w/v) 缩的3-HP.水溶液.
  • 证明了第一个集成的,完全无溶剂的DSP,用于生物基的3-HP.
  • 最低售价为0.551美元/千克 (溶液) 和0.892美元/千克 (盐),低于成本目标.

结论:

  • 开发的无溶剂DSP策略是高效的,可扩展的,经济可行的.
  • 这一途径使生物基3-HP的成本竞争性生产成为可能,用于生物烯酸等下游应用.
  • 该研究在平台化学品的可持续生物处理方面取得了重大进展.