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Updated: Jan 29, 2026

A Neurite Outgrowth Assay and Neurotoxicity Assessment with Human Neural Progenitor Cell-Derived Neurons
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Published on: August 6, 2020

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人类iPSC衍生神经元中的谷氨基质受体子单元的转录蛋白差异:对神经毒性测试的含义

Melania Maria Serafini1, Miriam Midali1, Giacomo Grumelli1

  • 1Department of Pharmacological and Biomolecular Sciences, "Rodolfo Paoletti", Università degli Studi di Milano, Milan, Italy.

Toxicology letters
|January 27, 2026
PubMed
概括

人类干细胞衍生的神经元显示出神经毒理学方面的前景,但需要更长的成熟时间. 对N-甲基-D-酸盐 (NMDA) 和α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) 受体的转录数据并不总是与这些模型中的蛋白质水平相匹配.

关键词:
这是一个AMPA受体.人类iPSC衍生的神经元这是一种NMDA受体.神经毒理学 神经毒理学综合生成 (Synaptogenesis) 是一种同源的过程.转录-蛋白质不一致性

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