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在日本和欧洲人群中,带血移植后的后续瘤
Junya Kanda1, Fernanda Volt2, Hanadi Rafii2
1Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan..
Transplantation and cellular therapy
|January 27, 2026
概括
在带血移植 (UCBT) 后的后续瘤 (SN) 在日本和欧洲之间在类型和结果方面显示出显著的区域差异. 这些发现强调了为长期患者护理量身定制的监测策略的必要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学
背景情况:
- 后续瘤 (SN) 是带血移植 (UCBT) 后的显著晚期并发症.
- 基于人口的数据,比较日本和欧洲之间的NS发生率和结果是有限的.
研究的目的:
- 对在日本和欧洲接受无关UCBT的患者中SN发生率,类型和结果进行比较分析.
- 为了确定在SN发展和UCBT后预后的区域差异.
主要方法:
- 一个回顾性,基于注册表的研究,利用来自日本和欧洲移植中心 (1998-2018) 的数据.
- 纳入标准侧重于非相关的UCBT接受者,他们发展了SN,不包括Fanconi贫血和初级固体瘤等特定疾病.
- 使用卡普兰-梅尔方法分析了整体存活率 (OS).
主要成果:
- 在日本,SN的发病率为3.2% (527/16241),在欧洲为2.2% (232/10358).
- 在日本,由捐赠者衍生的急性白血病/骨髓质疏松症候群 (AL/MDS) 的发生率更高 (58%对13%).
- 观察到明显的固体瘤形状,日本上部肠道癌更为常见,欧洲皮肤,甲状腺和软组织瘤更为普遍.
- 日本的五年后淋巴增殖障碍的生存率更高 (48%对23%),而固体瘤和AL/MDS的生存率相似.
结论:
- 在UCBT之后的SN类型和预测中存在显著的区域差异.
- 在捐赠者衍生的白血病和固体瘤类型中观察到的差异需要针对长期移植后护理的特定区域的监测策略.
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