药物类型是否会影响MRONJ手术的结果? 丹诺苏马布和佐勒德罗纳酸盐的比较
Jung-Hyun Park1, Soo Young Choi2, Anna Son3
1Associate Professor, Department of Oral and Maxillofacial Surgery, Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
概括
与药物相关的下巴骨 necrosis (MRONJ) 的手术结果在denosumab和zoledronate之间没有显著差异. 愈合和重新手术率更多地受到抗吸收疗法的原因和MRONJ阶段的影响.
科学领域:
- 口腔和牙面部外科手术
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 与药物相关的下骨硬化 (MRONJ) 是抗吸收疗法的严重并发症.
- 对MRONJ进行最佳的手术管理具有挑战性,需要对药物特定结果进行研究.
研究的目的:
- 为了比较手术后愈合和重复手术的患者在暴露于denosumab和zoledronate后进行手术治疗的MRONJ.
主要方法:
- 一项回顾性队列研究比较了暴露于denosumab或zoledronate的MRONJ患者的手术结果.
- 主要结局:完成临床愈合的时间. 二次结果:重新运行率.
- 统计分析包括卡普兰-梅尔,日志等级,考克斯回归和后勤回归.
主要成果:
- 在90名患者中,61名患者接受了登苏马布,29名患者接受了莱德酸盐. 总体愈合率为84.4%,代诺苏马布的中位愈合时间为3.0个月,佐勒德龙酸的中位愈合时间为5.0个月.
- 抗吸收剂类型没有显著影响愈合时间或重新操作率.
- 骨转移指示和MRONJ第3阶段与较差的愈合和增加的重新手术风险有关.
结论:
- 在MRONJ中,手术结果与抗吸收疗法的指示和MRONJ的阶段相比,与特定药物 (denosumab vs. zoledronate) 更密切相关.
- 这些发现支持目前的指导方针,强调基于阶段的管理和对临床背景的考虑.
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