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Updated: Jan 29, 2026

Reprograming Model of Human Monocyte-derived Macrophages for In-vitro Assays
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向AKR1B1重新编程与瘤相关的巨细胞,以增强抗瘤免疫力

Yuqing Liu1, Chao Zhou2, Yabin Tang1

  • 1Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Journal for immunotherapy of cancer
|January 27, 2026
PubMed
概括

向阿尔多基托减少酶家族1成员B1 (AKR1B1) 重编程免疫抑制性瘤相关巨细胞 (TAMs),以增强抗瘤免疫力. 这种方法可以改善T细胞功能,并在临床前模型中提高免疫检查点抑制剂 (ICI) 的有效性.

关键词:
免疫抑制是一种免疫抑制.免疫治疗是一种免疫疗法.固体瘤是一个固体瘤.瘤透淋巴细胞 - - TIL瘤微环境 - - 瘤微环境

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