血清溶解ASGR1度在患有与代谢功能障碍相关的脂肪性肝病的患者中升高,并与阿迪波内克丁相关
Jing-Ming Wang1, Li-Yan Jiang1, Yu-Ting Deng1
1Department of Metabolism and Endocrinology, First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
BMJ open diabetes research & care
|January 27, 2026
概括
血清溶解亚糖蛋白受体1 (sASGR1) 水平在患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者中升高. 较高的sASGR1与MASLD发生有关,表明其作为独立风险因素的潜力.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢综合征是代谢综合征的一种.
- 生物化学 生物化学
背景情况:
- 亚洲葡萄糖蛋白受体1 (ASGR1) 参与糖脂代谢和全身胰岛素抵抗.
- 血清中的器官蛋白表达与肥胖症中的炎症和胰岛素抵抗有关.
研究的目的:
- 调查血清溶解ASGR1 (sASGR1) 与代谢功能障碍相关的脂肪性肝病 (MASLD) 之间的关联.
- 评估sASGR1度与各种代谢,炎症和肝脏健康生物标志物之间的相关性.
主要方法:
- 该研究包括148名MASLD患者和98名对照.
- 使用ELISA套件测量了sASGR1,FGF21和皮蛋白的血清水平.
- 分析了临床特征和生物标志物水平.
主要成果:
- 与对照组相比,MASLD患者的血清sASGR1水平显著提高 (p<0.05).
- sASGR1与脂质/葡萄糖代谢指标,炎症标志物,肝功能/纤维化标志物和BMI正相关,与HDL-C负相关 (p<0.05).
- sASGR1成为MASLD的独立风险因素 (OR2.644,p<0.05),AUC为0.761用于预测,与AST/ALT结合时增加到0.863.
结论:
- 升高的sASGR1水平与MASLD有关.
- sASGR1可以作为一个独立的风险因素和一个潜在的预测生物标志物MASLD.
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