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石病:古石器时代的视角和生理学的预防方法
Calyani Ganesan1, Lynda Frassetto2, Alan C Pao1,3,4
1Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA;
Annual review of medicine
|January 27, 2026
概括
与古石器时代的饮食相比,现代人类的饮食中含有大量的和酸前体,显著增加了结石 (结石) 的风险. 采用古老的饮食模式可能会减少石头的风险.
科学领域:
- 进化医学是一种进化医学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养科学 营养科学
背景情况:
- 结石 (结石) 是一种具有复杂病因的普遍疾病.
- 人类的饮食在进化历史上发生了巨大的变化,特别是在过去的1万年里.
研究的目的:
- 探索古石器时代饮食对结石风险的影响.
- 研究农业和工业食品生产革命对结石形成的影响.
主要方法:
- 对进化和历史饮食证据的审查.
- 分析从高,低,富含的古石器时代饮食转向现代饮食的转变.
主要成果:
- 古石器时代的饮食的特点是高,低和高前体.
- 现代饮食,受农业和工业化的影响,高和酸前体,增加石头的风险.
- 这种突然的饮食转变挑战了的平衡,增加了结石形成的风险.
结论:
- 回到古石器时代的饮食模式可能会减轻结石的风险.
- 虽然化物,和empagliflozin等药物显示出潜力,但需要进一步的临床试验来确认它们在预防石头复发方面的有效性.
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