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卡尔-T细胞毒性和新兴的治疗策略

Amanda M Lulu¹, Erica Steele¹, Daniel W Lee¹

¹Division of Pediatric Hematology & Oncology, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virgina, USA;

Annual review of medicine

|January 27, 2026

概括

化学抗原受体 (CAR) T细胞疗法对固体瘤有望,但可能导致严重的毒性,如细胞因子释放综合征. 本综述详细介绍了这些不良事件及其管理策略.

科学领域:

免疫治疗是一种免疫疗法.
在瘤学瘤学.
细胞疗法细胞疗法

背景情况:

化学抗原受体 (CAR) T细胞疗法已经改变了B细胞恶性瘤和多发性髓瘤的治疗方法.
卡尔-T细胞治疗正在扩大到向固体瘤,为患者提供了新的希望.

研究的目的:

在固体瘤中审查与CAR T细胞治疗相关的急性毒性.
讨论这些毒性的临床表现,评估和管理.
探索CAR T细胞相关不良事件的病理生理学和新兴缓解策略.

主要方法:

对CAR T细胞毒性的临床表现,风险因素和病理生理学的文献综述.
讨论目前和新兴的毒性管理策略.
综合关于细胞因子释放综合征,神经毒性,血液毒性和HLH类综合征的信息.

主要成果:

对CAR T细胞治疗的抗瘤反应通常伴随着免疫过度激活.
关键的毒性包括细胞因子释放综合征 (CRS),免疫效应细胞相关的神经毒性综合征 (ICANS),血液毒性和血细胞淋巴细胞样性综合征 (HLH-like).
了解风险因素和病理生理学对于有效管理至关重要.

结论:

卡尔-T细胞疗法对固体瘤具有显著的潜力,但需要仔细管理相关的毒性.
评估,管理和减轻这些不良事件的有效策略对于成功的临床应用至关重要.
对毒性减轻的持续研究将对扩大CAR T细胞治疗的使用至关重要.

关键词:

在CAR T细胞疗法中.在CRS中,您可以使用CRS.美国国际航空公司 (ICAHT)在ICANS中,我们可以看到ICANS.在IEC-HS的基础上.仿制性抗原受体T细胞治疗T细胞治疗细胞因子释放综合征细胞因子释放综合征免疫效应细胞相关的血液毒性免疫效应细胞关联的血细胞淋巴细胞瘤样综合征.免疫效应细胞相关的神经毒性综合征

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