长期结局 诊断为不确定的结肠炎的儿童的长期结果
Serenay Cetinoglu1, Betul Aksoy1, Ilksen Demir1
1Department of Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Izmir Katip Celebi University, İzmir City Hospital, Izmir, Turkey.
概括
儿童无限性结肠炎 (IC) 往往具有显著的遗传突变,需要对自身免疫性疾病进行仔细监测,并可能被重新分类为性结肠炎或克罗恩病.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠病 (IBD) 研究研究
- 儿童自身免疫性疾病
背景情况:
- 不确定的结肠炎 (IC) 是炎症性肠病 (IBD) 的一个独特的亚型.
- 儿科IC的临床轨迹和结果仍然不完全理解.
- 这项研究旨在确定被诊断患有IC的儿童的随访过程.
研究的目的:
- 评估儿科不确定的结肠炎 (IC) 的临床结果.
- 确定IC儿童的相关自身免疫疾病和遗传因素.
- 评估长期疾病进程和IC的潜在重新分类.
主要方法:
- 在2010年至2022年期间被诊断患有IC的儿科患者的回顾性评估.
- 分析人口统计,家族史,实验室标记,血清学和诊断时的临床特征.
- 收集了结肠镜检查结果和长期随访数据.
主要成果:
- 在185例儿科IBD病例中,有29例 (15.7%) 被归类为IC.
- 超过四分之一的患者 (25%) 患有同时发生的自身免疫性疾病,主要是女性.
- 在诊断时48%的患者出现了全肠炎,其中13.7%的患者出现了肠外表现.
- 在20.6%的患者中发现IBD相关基因的遗传变异.
- 两名患者后来被重新分类为性结肠炎 (UC) 或克罗恩病 (CD).
结论:
- 建议对儿科IC进行遗传评估,特别是在那些同时出现自身免疫性疾病的人群中.
- 密切监测对于管理潜在的免疫相关并发症和治疗成功至关重要.
- 需要进一步的研究,以充分阐明疾病的过程,并优化对儿科IC的护理.
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